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They create a mini-placenta to study diseases during pregnancy.



Lara Press | EFEA group of researchers from the University of Cambridge published on Wednesday in the journal Nature about an innovative technique for analyzing the development of human placenta through laboratory cultures, which will increase the knowledge about diseases that arise during pregnancy.

The process consists in creating organoids, i.e. Miniature organ models that are developed in the laboratory and which allow you to know better how the placenta develops during pregnancy.

Thus, we can study some of the disorders that occur during this process, such as preeclampsia, growth restriction and fetal death, which have their origin in abnormal growth of the fetus inside the placenta during the first trimester.

Until now, knowledge of human placenta has been limited due to the lack of functional models created in the laboratory, with which it was possible to experiment, so that the development of organoids would allow the expansion of research in this area.

Scientists led by a professor at the University of Cambridge, Ashley Moffett, used long-term formation of organoid cultures created from trophoblastic cells that are extracted from the placenta during the first trimester between 6 and 9 weeks after gestation.

Crops grew rapidly, and during the first fifteen days they developed three-dimensional organoidal structures, and even three randomly selected cultures continued to grow after one year.

These organelles will also allow you to study the physiological, metabolic and hormonal changes that occur during pregnancy.

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