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From Maggie Fox
The National Institutes of Health is looking for a few good men to try out the new birth control gel for men.
Gel, daily rubbed into the shoulders, gradually reduces the number of sperm, so men can not make a woman pregnant. The National Institute of Child Health and Human Development (NICHD), which is part of the NIH, plans to register about 400 couples on sites around the world to check how well the gel works, to prevent pregnancy, and also to check how well people like it and will Do people use it as directed.
“This is the first time that men use it as part of a couple to test effectiveness,” said Diane Blyth, head of contraception development program at NICHD.
The gel composition, called NES / T, includes a progestin-containing compound, called segesterone acetate, which is produced under the trademark Nestorone, as well as a dose of testosterone.
“Applied on the back and shoulders and absorbed by the skin. Progestin blocks the natural production of testosterone in the testes, reducing sperm production to low or non-existent levels, ”the NICHD said in a statement.
It is formulated as a gel, because Nocomplex is not absorbed by the body when taken orally, and testosterone does not remain in the body for a full day when it is taken as a pill. Both hormones work longer and better when dosing through the skin.
There is currently no commercial male hormonal contraceptive on the US market. All men should choose from condoms or vasectomy.
“Globally, 85 million pregnancies (40 percent of all pregnancies) per year are unplanned, which contributes to a higher prevalence of adverse effects on the health of women and babies,” said a statement by the Population Council, which developed this product.
Incompatible, in combination with hormone estradiol, is also used as a female contraceptive. The product was approved by the US Food and Drug Administration in August as part of a vaginal ring for women to use as a birth control.
How can the same hormone work as a contraceptive in both men and women? This is due to the fact that many common hormones have similar chemical structures, Blyth said.
In men, hormone body tricks, thinking that he can stop doing sperm. In women, she mimics pregnancy and deceives the body, thinking that he can stop making eggs. “A man has a very low progesterone level. Now they are exposed to a large amount, and this tells the testes: “Oh, there are a lot of steroids, so I no longer need to do more,” said Blyth.
According to Blyth, giving up some testosterone along with nestorone stops unwanted side effects, such as low libido and muscle loss.
One question is how effective the treatment will be. Different birth control methods have different efficacy.
“If we are talking about a daily pill for women, if they use it well, the failure rate is extremely low,” said Blyth. “With typical use, the failure rate is 7 percent. With condoms, if used excellently, the failure rate is low, but with typical use, the failure rate is 12 percent. ”
In theory, men could forget to use the gel throughout the day without any consequences. “If they stop using it for three, four or five days, then it will not work as intended,” said Blyth.
"I think they will use it?" Of course, they are able to use it, and they are ready to use it. But people are people, people forget. ”