Scientists have developed a new drug that can block glioblastoma – the most deadly form of brain cancer – from spreading.
The tissues in our bodies are mostly fluid. It moves around the cells and is essential for normal body function. But in some cases this liquid can do more harm than good.
In people who have glioblastoma, this fluid has a much higher pressure, causing it to move quickly and causing the cancer cells to spread.
Researchers said that the drug AMD3100, which has already been used in clinics, has proven effective in preventing the inevitable spread of cancer cells.
“I hope that since the drug we used to block the flow stimulation is currently being used in patients, who may be doctors, when they believe that they are using improved convection, they will combine this with this drug,” said the facilitator. author Chase Cornelison, a postdoctoral researcher at the Virginia Polytechnic Institute and State University.
In a study published in the journal Scientific Reports, the team investigated the flow of interstitial fluid that surrounds cells in the body, in the distribution of glioma cells.
Consisting of circulating cerebrospinal fluid, cellular waste and blood plasma, interstitial fluid flow was previously associated with an increased rate of invasion of glioblastoma or tumor cells of the brain.
The researchers tested the drug AMD3100 and found that it can block the rapid movement of intramuscular fluid from the brain and the spread of cancer cells.
They also tested the drug in glioblastoma mice to test how a special approach to cancer treatment, called increased convection, caused glioma cells to invade the rest of the brain.
“This (glioblastoma) is so deadly, and for decades there has been no change in the response to treatment. Something needs to be changed … If you look at the flow of fluid, maybe there is an answer that we have not seen, ”added Jennifer Munson, associate professor.
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