They hope that one day their project will lead to much cheaper vital treatments. Protein drugs, such as the Herceptin and Avastin biologics (the latter are also used as a wet form of age-related macular degeneration), can be effective in rejecting well-known pharmaceutical products, but their disadvantage is that they are very expensive, BBC reports. The survey conducted at the institute Roslyncan lead to cheaper manufacturing processes, reports the Slovenian news agency.
Publication in the scientific publication BMC Biotechnology,
A team of researchers from the Roslin Institute changed the chicken genome to contain a large amount of high-quality proteins in their eggs. According to them, three eggs contain a dose of clinical effect, and chickens spend hundreds of eggs a year.
These proteins will now be used for the first time in research, but laboratory tests have already shown that they are just as effective as comparable drugs.
What are they really secret …
At the moment, the chickens have been genetically modified to produce two types of proteins. One of them is actually a macrophage. CFSwhich can be used to stimulate damaged tissue in order to restore it. They develop it in human and swine variants.
Other interferon alpha 2aIt is a human's own protein, which reacts as part of the human immune system. According to the doctor, has anti-virus features Lisse Herron Roslin Technologies also found antiknock properties. "This is a protein that has been used for some time to treat hepatitis in certain forms of cancer." she added.
… and what else could be
The research team is convinced that a set of proteins that will “roll” transgenic chickens, Uncover it. Chickens themselves do not affect the presence of human proteins in the body, they also live better than the battery-fed chickens, as eggs are usually used as usual.
More eggs in the presence of a rooster
The study is conducted in a protected room at the Roslin Institute, where dozens of transgenic animals are raised in spatial chickens, the task of which is to boil 300 eggs per year. They also play a double role in the company.
Hens more often throw eggs if there are roosters nearby. In addition, several males of transgenic birds are required for breeding. They are not clones, but come to the world in the usual biological way.
“In the chicken coop we have a rooster that can produce a lot of chickens in a very short time.” said Professor Helen Sung from the institute.
Cannot be produced in the laboratory.
Eggs rolled up by chickens are then moved to a cacophony of chickens separately from the laboratory, where they break down and the egg yolks are separated from the proteins. Rummenovci does not use, and protein, which contains a large number of medically important proteins.
“These proteins are really expensive to produce because they cannot be synthesized in the laboratory.” said Dr. Herron. "They need a living system, because proteins are very large and very complex molecules, for the correct production of which the entire structure of the cell is required." Herron added.
Thus, transgenic chickens can become pioneers in the production of better and cheaper drugs. Even in this study, as with all those who promise, there is a problem. The actual development of the turning point should also take decades of further research and experimentation. The path to t. I. Orphan drugs for the treatment of rare diseases can be much shorter, and drugs for animals are available on the market even earlier, according to STA.