Some are bigger than others, but in general most people have hair in areas of the body like head, legs or armsHowever, in others, such as the palms of the hands or the soles of the feet, there is not the slightest hint of hair, regardless of gender, age, or tendency to the hair of a person. Why is this?
This is a question that many scientists have asked, and now a group of researchers from University of Pennsylvania, in order to apply this knowledge to treat baldness or hair regrowth in Burn scars and large woundsIn addition, its results, which were published today in Cellular Reports, explain why some animals, such as rabbitsthey have hair on parts of the body where other rodentslike mice, no.
Prohibition of more "hairy" signs
The gene that encodes an inhibitor of the signaling pathway involved in the development of hair follicles is expressed on the palms of the hands and the soles of the feet
These researchers focused their research on WNT signaling pathknown to play an important role in development of hair follicles and hair growth, It is clear that under normal conditions this route works fine in areas of the body, such as legs or hands, but it does not work in other areas, such as palms of hands,
The answer, as these scientists describe in their study, is in a protein inhibitor of the indicated pathway, called Dickkopf 2 (DDK2)They checked that the gene that encodes this protein is found very pronounced in the plantar skin of micein which, as in the soles of human feet, hair does not grow. However, if it is inactive Hair begins to develop, as in the rest of the body. It shows that WNT path is also found in these areas.but paralyzed through action DDK2,
Finally, they found that this gene is not expressed in rabbits, so his skin, like that of polar bears, yes he has hairThis shows that throughout the evolution of this path different ways, depending on the specific needs of each species animal.
It all answers curious question that we have done this for a long time, but the goal of this group of scientists goes much further.
It is known that hair follicles develop in human fruitsbut stop production after birthThat is why when a big burn or wound heals, new skin is missing in the hair, In search of a solution to this problem, they suggested check DDK2 one that is involved in the paralysis of the development of hair follicles; since, if so, in these particular cases it can be reactivated in favor of new skin with hair.
But, above all, the greatest concern about the lack of hair is associated with people with alopecia. According to the Spanish Academy of Dermatology and Venereology (AEDV), 40% of men aged 18 to 39 years suffer Androgenic AlopeciaIn addition, the percentage reaches 95% in men with age over 70 years old,
Although it does not involve health problems, it is often accompanied by large dissatisfied with the physical aspect, so many scientists are trying to find a solution. Previous studies found DKK2 as potential candidate the emergence of this gradual hair loss, so these researchers also intend to focus the next steps of their work on analyzing this. No doubt, if they manage to get to a good port, many people will be happy with their conclusions.
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