CIC bioGUNE leads RedHYPOX, a thematic network of research in the field of hypoxia, formed by ten research groups, with a common interest in studying various mechanisms that mediate responses to hypoxia (oxygen deficiency) and its relevance in physiological and pathological situations.
BILBAO. According to CIC bioGUNE, the study of the cellular and molecular basis of the response to hypoxia is the subject of great interest in biomedicine. “The task is there and the expectations are very ambitious from both a basic and an applied point of view, since the fruits of research may present new opportunities for understanding and improving the diagnosis and treatment of diseases that are endemic to our society,” said Dr. Edurne Berra, Network coordinator and responsible for the HypoxiPATH group from BIGGUN.
For two days, research staff from the Excellence in Hypoxia thematic research network, an initiative funded by the Ministry of Science, Innovation and Universities, met in Granada. The meeting was attended by experts, international referents in their respective fields, in various fields of knowledge.
RedHYPOX combines a range of experimental approaches, ranging from computational approaches to clinical research, with a wide range of cell and animal models, as the research center explains
RedHYPOX members belong to a wide range of institutions that have a “solid track record” in basic and translational research, including several universities (Autonomous University of Madrid, Complutense University of Madrid and University of Seville), hospitals (Hospital vall d &; Hebron and Hospital de la Princesa) and research centers (CIC bioGUNE, IBiS and IBSAL).
CIC bioGUNE showed that oxygen is vital and most cells are “dependent” on oxygen. This is so that its deficiency (or hypoxia), even transient, can have dramatic consequences. Therefore, organisms have developed mechanisms that at different levels allow them to react, adapt and guarantee oxygen homeostasis.
“Hypoxic” episodes occur during fetal development and in healthy adults, for example, during the acclimatization of height, wound healing or exercise. Moreover, the use of more or less complex hypoxic equipment to improve athletic performance is relatively common.
But insufficient oxygen supply (excessive or defective) is also associated with diseases such as cancer, metabolism (eg, diabetes), inflammatory (eg, Crohn), neurodegenerative (Alzheimer's and Parkinson’s disease) or ischemic diseases (eg, stroke and stroke) .